As for Diego Simeone's Atletico, Los Rojiblancos will be without their coach on the touchline following his sending-off in the semi-finals, as the Spanish club look to win a third Europa crown since 2010.
Marseille - the first club to win the current Champions League format in 1993 - make the short trip north as they aim to claim their first Europa League crown.
The French club started their Europa campaign early in the third qualifying round. Marseille have managed to win eight out of their nine European home games this term, but the side's away form will be slightly worrying heading to a neutral ground - competing away from the Stade Velodrome in Europe, Marseille have won just once in nine.
Having come runners-up in the 1998-99 and 2003-04 UEFA Cups, Marseille have now reached the Europa League final at the fourth time of asking. The club currently sit fourth in Ligue 1 and are one point outside of the Champions League spots. They will either need to win the final or usurp third-placed Lyon on the final day of the domestic season should they want to feature in the elite competition next term.
Facing Spanish opposition, Marseille have won just four of their 15 UEFA games, losing eight of those contests. What will please coach Garcia, however, is that his side have already won twice against Athletic Bilbao in this term's round of 16.
To combat Atletico's recent continental experience, Marseille will be relying on the likes of Dimitri Payet, Adil Rami and Luiz Gustavo. Payet has recorded seven assists, the most by any player in this season's tournament
As for Rami, the centre-back has started 16 of Marseille's 18 European encounters and also won the tournament when playing in defence for Sevilla during the 2015-16 season. Gustavo is the only Marseille player to have started all of the team's 14 matches in the competition this year.
OM head to Lyon knowing that no French side has ever won the UEFA Cup or Europa League, but given the number of games they have played this term, combined with some of their mercurial talents, Marseille might just fancy themselves to rewrite history at the Stade de Lyon.
Recent form: WWDLWD
Recent form (all competitions): DWWDWD
Atletico enter Wednesday's final looking to add another piece of European silverware to an already-laden collection, but the club will be without boss Simeone on the touchline, as he continues to serve a four-match ban following his dismissal against Arsenal in the semis.
Simeone's charges have won the Europa League twice already, collecting the inaugural prize in 2010 before coming back to win the tournament again in 2012.
Atletico have had a five-year absence from the competition and have put that time away to good use in the Champions League. Madrid have taken part in two Champions League finals, a semi-final and a quarter-final during their break from the Europa.
On the club's way to the final in France, Atletico reached the knockouts after a lacklustre showing in the Champions League group stages. Entering the Europa, Madrid have since knocked out FC Copenhagen, Lokomotiv Moscow, Sporting Lisbon and Arsenal.
Against Arsene Wenger's charges, Madrid showed commendable tenacity and industry despite not being at their best. The two-time winners are in the final after producing a standout collective effort to draw 1-1 at the Emirates with 10 men, before capping off an impressive display to win 1-0 back in the Spanish capital.
Atletico have managed to win three out of the eight major UEFA competition finals that they have reached in the club's history. Those cup-winning efforts came in the 1962 European Cup Winners' Cup and in the 2010 and 2012 incarnations of the Europa League.
The club travel to Lyon having lost just one European away game outside of Madrid this term. Atletico are currently sitting in second place in the La Liga standings and require just a single point on the final day to claim the position and finish above city rivals Real Madrid.
Fellow Spanish side Sevilla are the only club to win three Europa League crowns and Atletico now have the opportunity to match Los Hispalenses. Coach Simeone is the only non-European manager to win the Europa League.
Recent form: WLDWLW
Recent form (all competitions): DDWWLW
Rolando is still likely to be struggling with a knock, meaning that Gustavo should continue alongside Rami at centre-back.
Marseille possible starting lineup:
Pele; Sarr, Rami, Gustavo, Amavi; Lopez, Sanson; Thauvin, Ocampos, Payet, Germain
Atletico Madrid possible starting lineup:
Oblak; Juanfran, Godin, Savic, Luis; Correa, Gabi, Saul, Koke, Costa, Griezmann
Head To Head
The only previous two fixtures between the teams came in the 2008-09 Champions League group stages.
Atletico, led by former boss Javier Aguirre, beat Marseille 2-1 in the Spanish capital in the opening fixture, before the reverse saw a goalless draw played out in France.
Atletico have only lost one game against a French side. That defeat came against Lens in the fourth round of the 1999-02 UEFA Cup. Marseille have lost eight out of 15 against teams from Spain.
We say: Marseille 1-2 Atletico Madrid
OM have a Champion League title to their name, but that success came over a decade ago. At times this season the French club have proven destructive going forward and they stand a chance should the likes of Payet and company rise to the occasion.
Atletico have crucial experience in both Champions League and Europa League finals, coming into this tournament having won it twice already.
The club will be missing Simeone on the touchline, although this Madrid squad has so many experienced players when it comes to UEFA competitions that the Argentine's absence may not be too destructive to Atletico's chances.