Hapoel Tel Aviv will play host to Spaniards, having qualified for the competition thanks to their success in this year's Israeli State Cup.
They are in good form heading into the encounter, winning all of their last five matches and conceding just one goal in the process.
Atletico are expected to start with the in-form Falcao in attack. The Colombian has already scored seven goals this season and he also has 29 Europa League goals to his name from the last two campaigns.
Hapoel: Edel; Pantsil, Antebi, Shushan; Djemba-Djemba, Bruno Coutinho, Vermouth, Badir, Maman; Tamuz, Ben Haim
Atletico: Courtois; Juanfran, Miranda, Godin, Luis; Turan, Gabi, Tiago, Koke, Diego; Falcao
Sports Mole says: 1-1