After all, Los Rojiblancos are attempting to win the competition for what will be the third time in just four seasons.
They also have a positive home record, having not lost a match in Europe's second tournament since they were defeated 3-2 by Aris Thessaloniki in December 2010.
However, Kazan have positive memories of their visits to Spain. In 2009 they caused an upset by beating eventual winners Barcelona 2-1 in the Champions League at Camp Nou.
This is the fourth campaign in succession that the Russian side have reached this stage.
Atletico Madrid: DWWLWL
Rubin Kazan: WDLLLL
Possible starting lineups
Atletico Madrid: Courtois; Miranda, Juanfran, Cisma, Godin; Gabi, Suarez, Turan, Koke; Adrian, Falcao
Rubin Kazan: Arlauskis; Bocchetti, Kuzmin, Ansaldi, Marcano; Sharonov, Orbaiz, Karadeniz, Eduardo; Kasaev, Rondon
Sports Mole says: 3-1