If Diego Simeone's side avoid defeat at the Estadio Ramon Sanchez Pizjuan tomorrow night, they will advance through to May's showpiece event at the expense of Sevilla, who trail 2-1 from the opening leg in the Spanish capital.
Incidentally, Negredo is the competition's leading goalscorer along with Atletico's Diego Costa on six goals.
The home team head into the tie with a negative recent record against Atletico, having not beaten them in their last six attempts - a run that dates back to October 2010.
Possible starting lineups
Sevilla: Beto; Coke, Fazio, Spahic, Navarro; Kondogbia, Medel; Navas, Morel, Reyes; Negredo
Atletico: Courtois; Juanfran, Godin, Diaz, Luis; Tiago, Suarez; Adrian, Turan, Rodriguez; Falcao
Sports Mole says: 1-1