Inter are currently second in the table, one point clear of third-placed Atalanta, while fourth-placed Lazio are also in the race for second entering the final weekend of action in Italy's top flight.
Atalanta have never finished second in Serie A, while they were a bottom-half team between 2011 and 2016, having only secured a return to the top flight for the 2011-12 campaign.
La Dea have improved considerably in recent years, though, and will be determined to pick up all three points on Saturday to secure second before turning their attention to the Champions League, where they will face Paris Saint-Germain in the quarter-finals of the European competition on August 12.
Atalanta will enter this match off the back of a 2-1 success at Parma on Tuesday night, while they are unbeaten in Serie A since January 20. A record of 23 wins, nine draws and five defeats from 37 matches has left them in third, just five points behind the champions Juventus.
Gian Piero Gasperini's side are level on points with fourth-placed Lazio but sit third due to their superior head-to-head record, meaning that a victory over Inter would guarantee second spot in the table.
Atalanta will also be hoping to break the 100-goal mark in Serie A this weekend, having found the back of the net on 98 occasions in their 37 league games thus far, which is 23 more than Juve.
Inter, though, will also be desperate to secure second, which would represent their best placing in Italy's top flight since 2010-11. Indeed, they have not finished higher than fourth in any of their last eight campaigns.
The Milan giants have fallen just short in terms of the title, but there is no question that the team have made significant progress under the leadership of Antonio Conte.
I Nerazzurri already have more points (79) than they have managed in any season since winning the title in 2009-10 (82), and the fact that they could equal that return this weekend is an indication of their improvement.
Inter were held to successive draws by Roma and Fiorentina on July 19 and July 22, but they have impressively won their last two, beating Genoa 3-0 on July 25 before recording a 2-0 success over Napoli on Tuesday night.
A win on Saturday would secure second spot in the table, although a point would also be enough for the runners-up position should Lazio fail to win at Napoli on the same night.
Atalanta Serie A form: DWDWDW
Inter Serie A form: WWDDWW
Atalanta will again be without the services of Josip Ilicic through injury, while central defender Jose Luis Palomino is a doubt with the muscular problem that forced him off in the first half of the clash with Parma.
Gasperini has decisions to make when it comes to the final third of the field, but it seems likely that Duvan Zapata will again get the nod over Luis Muriel alongside Alejandro Gomez and Mario Pasalic.
Diego Godin and Milan Skriniar should also return to the starting side, while Ashley Young and Christian Eriksen could come in for Cristiano Biraghi and Borja Valero as Conte prepares to shuffle his pack.
That said, Gagliardini's availability could see Marcelo Brozovic pushed further forward to the position just behind Romelu Lukaku and Martinez, meaning that Eriksen would likely start on the bench once again.
Atalanta possible starting lineup:
Gollini; Sutalo, Caldara, Toloi; Castagne, De Roon, Freuler, Gosens; Pasalic; Gomez, Zapata
Inter possible starting lineup:
Handanovic; Skriniar, De Vrij, Godin; Candreva, Barella, Gagliardini, Young; Brozovic; Lukaku, Martinez
We say: Atalanta 1-1 Inter Milan
There is no downplaying the importance of this match to both teams, despite the fact that neither can win the title. A point would be enough for Inter if Lazio do not overcome Napoli, and we are finding it difficult to separate these two sides on Saturday night, backing a low-scoring draw at the Gewiss Stadium.