The two sides have almost identical records after eight games, managing two wins and sitting just above the bottom three, meaning that victory would represent an important psychological boost early in the campaign.
While many would have been surprised to see Villa come away with a 5-1 win over Norwich City at Carrow Road last time out, Dean Smith's players will strongly feel that the result serves as overdue reward for the work they have put in since August.
Two goals from new signing Wesley, combined with a performance hallmarked by sheer pace, highlighted how this Villa team can look comfortable at this level when all of its moving parts are working.
Having deservedly lost three of their opening four games, Villa's performances contained greater purpose and intensity during the next four, as seen most pertinently in an agonising last-minute 3-2 defeat to Arsenal at the Emirates.
However, Villa will need to complement that requisite intensity with cutting edge in the final third if they are to stay up, placing extra importance on Wesley and John McGinn, two signings who have already looked sharp, alongside the captain Jack Grealish.
The Villans have an excellent chance to further boost their confidence in the final third this weekend against a Brighton side which has only managed one win from its last nine away games in the league.
Brighton's last outing, a convincing 3-0 win over a poor Tottenham Hotspur side, was similar to Villa in the sense that it arrived at a time when results had not been going their way.
Having failed to win since the opening day of the season, the Seagulls went about their business against Mauricio Pochettino's side like a team with nothing to lose, setting in motion a physical, tactically astute performance.
The dynamic will change when they travel to Villa Park for a game which will no doubt contain fewer clear opportunities and one likely to be decided by fine margins.
New boss Graham Potter would have been encouraged by the killer instinct shown by youngster Aaron Connolly against Spurs, with the 19-year-old dovetailing impressively with Neal Maupay and producing two classy finishes.
This partnership up front is likely to be vital if Brighton are to gain a foothold against Villa in a game with a different feel compared to the assault on Spurs.
Recent Aston Villa form: LDLLDW
Recent Brighton & Hove Albion form: LDDLLW
Aston Villa possible starting lineup:
Heaton; Guilbert, Engels, Mings, Targett; Nakamba, McGinn, Hourihane; Grealish, El Ghazi, Wesley
Brighton and Hove Albion possible starting lineup:
Ryan; Montoya, Webster, Dunk, Burn; Stephens, Alzate, Mooy, Groß; Connolly, Maupay
We say: Aston Villa 1-1 Brighton & Hove Albion
With just one point separating these sides in the table and both teams wary of the consequences of defeat, expect a cagey affair devoid of many opportunities at Villa Park this weekend, with space being minimised wherever it may present itself. A low scoring draw is therefore the most likely outcome.