They could move to within just one point of the current champions with a win at the weekend, while Rennes are just three points away from the top six, despite residing in 11th place.
The visitors have secured just one victory in their last six, with their latest match resulting in a 1-1 draw with Bordeaux.
Both sides have kept just five clean sheets in the league so far, which indicates that goals could be on the cards.
AS Monaco: WDWLDW
Possible starting lineups
AS Monaco: Subasic; Raggi, Kurzawa, Carvalho, Abidal; Toulalan, Obbadi, Moutinho, Rodriguez; Riviere, Falcao
Rennes: Costil; M'Bengue, Kana-Biyik, Armand, Danze; Kadir, Makoun, Hunou, Oliveira; Konradsen, Alessandrini
Sports Mole says: 2-1