Arsene Wenger's decision to stick with a back four means that 20-year-old Maitland-Niles is selected over Sead Kolasinac, while Wilshere benefits from the absence of Aaron Ramsey in the middle of the park.
As for Liverpool, Andrew Robertson and Ragnar Klavan both start due to the absences of Alberto Moreno and Joel Matip, while Sadio Mane starts alongside Roberto Firmino and Mohamed Salah in the final third.
Former Arsenal midfielder Alex Oxlade-Chamberlain is on the bench for the away side.
Arsenal: Cech; Bellerin, Koscielny, Monreal, Maitland-Niles; Xhaka, Wilshere; Iwobi, Ozil, Sanchez; Lacazette
Subs: Ospina, Mustafi, Kolasinac, Coquelin, Elneny, Walcott, Welbeck
Liverpool: Mignolet; Gomez, Lovren, Klavan, Robertson; Henderson, Can, Coutinho; Salah, Firmino, Mane
Subs: Karius, Alexander-Arnold, Lallana, Oxlade-Chamberlain, Wijnaldum, Milner, Solanke
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