The Frenchman makes five changes from the side that were defeated 3-1 at Leicester City in midweek, with Lacazette replacing Danny Welbeck up front alongside Pierre-Emerick Aubameyang and Henrikh Mkhitaryan.
Aaron Ramsey, Alex Iwobi and Granit Xhaka continue in the midfield, while Hector Bellerin and Shkodran Mustafi replace Ainsley Maitland-Niles and the suspended Kostas Mavropanos in the defence alongside Rob Holding and Sead Kolasinac.
Elsewhere, Jack Wilshere fails to return to the matchday squad after missing the loss to the Foxes due to the birth of his daughter.
Huddersfield Town: Lossl; Hadergjonaj, Jorgensen, Schindler, Kongolo, Lowe; Hogg, Mooy, Pritchard; Ince, Mounie
Subs: Coleman, Smith, Whitehead, Billing, Sabiri, Depoitre, Stankovic
Arsenal: Ospina; Bellerin, Mustafi, Holding, Kolasinac; Ramsey, Xhaka, Iwobi; Mkhitaryan, Aubameyang, Lacazette
Subs: Macey, Maitland-Niles, Mertesacker, Monreal, Willock, Welbeck, Nketiah
Keep up with all of the action from Wenger's final Arsenal game this afternoon with Sports Mole's live text commentary here.