Southampton have finally suffered more disappointment after proving their doubters wrong throughout the early stages of the new season.
Going two games without a win may have not been a concern before, but there have been suggestions that the Saints could slip further down the table after losing 3-0 to Manchester City on Sunday afternoon.
Ronald Koeman was understandably disappointed as his side lost for just the third time this season, but he will be hopeful that his players will produce a quick response at the Emirates Stadium, where they recorded a 2-1 win in the League Cup back in September.
For Arsenal, the weekend was a positive one as Danny Welbeck handed them a 1-0 victory over West Bromwich Albion just days after a comfortable win over Borussia Dortmund had booked their spot in the next round of the Champions League.
Doubts remain over Arsenal's ability to go on an extended run, but the win against the Baggies would have given the fans confidence heading into a hectic December schedule.
However, Arsene Wenger heads into the game with another defensive crisis brewing due to injuries picked up by Nacho Monreal and Kieran Gibbs.
Reports have suggested that Mathieu Flamini could be asked to fill in at left-back as a replacement for the injured duo.
Southampton are sweating over the fitness of Morgan Schneiderlin, but there could be a recall for Shane Long, who started the game against City on the bench.
Arsenal:
Form in Premier League: DWWLLW
Form in all competitions: WDLLWW
Possible starting lineup: Martinez, Chambers, Mertesacker, Koscielny, Monreal, Flamini, Ramsey, Welbeck, Sanchez, Cazorla, Giroud
Southampton:
Form in Premier League: WWWWDL
Form in all competitions: WWWWDL
Possible starting lineup: Forster; Clyne, Fonte, Yoshida, Bertrand; Wanyama, Alderweireld, Tadic; Long, Mane, Pelle
Sports Mole says: 2-1
Callum Mulvihill
