Tensions over the Spanish government's response to the Catalan independence referendum led to some, including Catalonia sports minister Gerard Figueras, to suggest that Barca could one day play in the English top flight.
Wenger, however, does not feel that the prospect is realistic or desirable in resolving a complicated political situation.
When asked if he would want Barcelona in the Premier League if they leave La Liga, the Frenchman told beIN Sports: "No, because as soon as you disturb the geographical unity or common sense, I believe it would not be normal. Why not invite Celtic or Rangers to the Premier League, who are part of Great Britain, it makes more sense than to invite Barcelona?
"On a second level as well, if it doesn't go well politically between Catalonia and Spain, it would mean a stand of support for Catalonia from England which certainly would not be welcome internationally politically.
"I don't believe it is a scenario you can envisage in a realistic way. And I hope as well that it will not go as far and Barcelona can continue to play in Spain."