The 42-year-old will be managing in the fixture for the first time, and he feels that his side have to be willing to put everything on the line to get a positive result for their supporters at the Emirates Stadium.
Pochettino told Sky Sports News: "Playing Arsenal is not another game - it's impossible to think it is. I know the feeling of our supporters and we need to relay this feeling on the pitch.
"It's our responsibility to fight for every ball. Our supporters expect that of us. If we do then the result may arrive for us. I'm stronger with hostile situations. It's not strange for me. I like it."
Tottenham are currently ninth in the Premier League after five matches this season.