Wenger made a full 11 changes to his starting lineup for the quarter-final tie, coming just three days before a crunch clash with Liverpool - the first of 10 games in the space of 36 days.
Speaking after the match, the Frenchman told reporters: "It is very demanding, especially because we already have a tough schedule behind us.
"We have to sit down and analyse very well what we can do. What is very worrying in my job is when you start to lose players, like Giroud tonight.
"After, you cannot afford to lose another one. I have to look how I can manage the schedule. When you look at our fixtures in January and February, you cannot imagine we will always play with the same players in every game.
"Will I change from Premier League game to Premier League or only in the Carabao Cup? I don't know yet – I have to look at the fixtures to see what I do."