Palmeiras vs. Catolica (Wednesday, 11.15pm)
The Chilean visitors head to Brazil hoping to overturn a one-goal deficit from the first leg, as they aim to reach the last eight for the first time in 10 years.
We say: Palmeiras 2-0 Universidad Catolica
Palmeiras have found their groove over the last month and as strong favourites for Wednesday's match, the hosts are expected to extend their winning run to eight games.
Even though Catolica are sure to put up a fight, the defending champions should have no problems in progressing to the quarter-finals.
Barcelona vs. Velez Sarsfield (Wednesday, 11.15pm)
The visitors take a narrow 1-0 advantage to the Estadio Monumental Banco Pichincha, as they look to progress to the quarter-finals for the first time since 2012.
We say: Barcelona SC 2-1 Velez Sarsfield
Even though Velez have looked strong defensively of late and kept a clean sheet in the first leg, Barcelona SC have shown their attacking qualities during this competition; and with goals needed to progress, we can see the hosts finding the net on Wednesday.
Another closely-fought contest is set to be played out in Ecuador, and we think that Barcelona SC may secure a slender victory by a one-goal margin, which would be enough to see them progress on away goals.
Flamengo vs. Defensa (Thursday, 1.30am)
The two sides faced each other for the first time last week, with the Brazilians securing a narrow 1-0 victory against their Argentine counterparts in the first leg.
We say: Flamengo 1-0 Defensa y Justicia
With Defensa y Justicia needing to score if they are to progress to the quarter-finals, the pressure is on them to take the game to Flamengo and make life difficult for the hosts.
However, Gaucho has had an instant impact at his new club, making the Scarlet-Black difficult to break down. The Brazilians will be keen to make amends for last season's elimination at this stage and we can see them securing another narrow victory on Thursday.
Argentinos Jrs vs. River Plate (Thursday, 1.30am)
After drawing the first leg 1-1 last week, the hosts will be looking to reach only their second ever quarter-final, while the visitors are hoping to progress to their fifth in succession.
We say: Argentinos Juniors 1-2 River Plate
A tight encounter between two evenly-matched sides is set to be played out on Thursday, with River Plate knowing that they need to score if they wish to progress.
The visitors have not performed particularly well of late, but they have an impressive record during the Copa Libertadores knockout stages. Even though Argentinos have made themselves difficult to beat in recent months, we feel that River Plate could turn up for the big occasion in Buenos Aires and seal a narrow victory.