Meanwhile, the visitors have put together a four-match unbeaten streak in the Dutch top flight, moving the club to within three points of fourth position.
Heading into the closing stages of last week's contest with rivals PSV Eindhoven, it appeared that Ajax were on the brink of losing their 11-match winning streak in all competitions and subsequently allowing PSV to get back into the title race.
However, having seen the hosts denied a second goal through VAR, the leaders netted a last-minute penalty through Dusan Tadic, delivering a hammer blow to their opponents.
While the gap remains just six points, there is a feeling that PSV have missed their chance to stay in the race for the top-flight crown, particularly having played a game more than Ajax.
Erik ten Hag's team are fully focused on winning the treble, a target made easier by their triumph over Heerenveen in the KNVB Beker semi-finals in midweek.
Ajax have now avoided defeat on the domestic scene since December 5 and it is difficult to see any of their upcoming opposition stopping them in their tracks.
From Groningen's perspective, they can take confidence from now possessing the second best defensive record in the division courtesy of their recent performances.
Just one goal has been shipped in four fixtures, leaving Danny Buijs's team with a record of just 24 strikes being conceded from as many matches this season.
The Trots van het Noorden also edged out Ajax in the reverse fixture back in October, a result which has contributed to Groningen holding one of the best returns at home.
However, as well as scoring just three goals in their most recent five fixtures, Groningen have also failed to win any of their last three away games.
Even with a Europa league last-16 tie against Young Boys on the horizon, Ten Hag is unlikely to name a weakened team for this game.
Buijs must decide whether to hand an opportunity to teenage striker Paulos Abraham, who scored his first senior goal off the substitutes' bench against Fortuna Sittard.
Jorgen Strand Larsen will expect to keep his place in the side providing that he has shaken off the knock which forced his withdrawal at half time.
Ajax possible starting lineup:
Stekelenburg; Rensch, Timber, Martinez, Blind; Alvarez, Gravenberch; Antony, Klaassen, Tadic, Haller
Groningen possible starting lineup:
Padt; Dankerlui, Te Wierik, Itakura, Hintum; Kaam, Schreck; Cruz, Suslov, Hankouri; Larsen
We say: Ajax 3-0 Groningen
After their near-miss against PSV, complacency is unlikely to be a factor at Ajax for the remainder of the season. With that in mind, we are backing the home side to cruise to victory, their cause helped by a couple of early strikes.