AC Milan coach Filippo Inzaghi will be hoping that his team can show immediate improvements at the start of the domestic season after a dismal pre-season campaign.
I Rossoneri suffered defeats in their final four friendlies as they look to better their eighth-place effort in Serie A last year.
Summer signings Diego Lopez, Pablo Armero and Adil Rami could feature in the starting lineup at the San Siro.
It has been a summer of change at Lazio after Stefano Pioli was installed as the club's new manager, with Edoardo Reja only leading the Rome-based side to ninth place last season.
Pioli is likely to hand starts to a number of his team's new additions, with Stefan de Vrij, Dusan Basta and Marco Parolo all likely to feature in Milan.
Lazio prepared for the start of Serie A with a 7-0 victory over Bassono Virtus in the Coppa Italia.
Recent form
AC Milan: WLLLL
Lazio: WLWDW
Possible starting lineups
AC Milan: Diego Lopez, Bonera, Rami, Abate, Albertazzi, Muntari, Honda, Poli, Essien, Pazzini, El Shaarawy
Lazio: Berisha, Basta, Radu, De Vrij, Cana, Ledesma, Lulic, Parolo, Felipe Anderson, Dordevic, Keita
Sports Mole says: 1-1
Darren Plant
