The Lakers got their noses in front of the Utah Jazz in the third quarter and extended their lead down the stretch with Anthony Davis scoring 42 points while LeBron James had 22 points, nine assists and eight rebounds in the 116-108 win.
LA have missed the post-season in the last six campaigns and last topped the Western Conference in 2009-10 when they saw off the Boston Celtics to take the NBA Finals.
Fred VanVleet proved pivotal to Toronto's success with a career-high 36 points, while Pascal Siakam hit 22 and Kyle Lowry 14 as the side followed up their upset win over the Lakers with another victory.
Toronto are unlikely to topple the Milwaukee Bucks for the top seed in the Eastern Conference but have the best form in the NBA ahead of the playoffs starting on August 17.
Elsewhere, the Philadelphia 76ers held off a late run from the San Antonio Spurs to record a 132-130 win, with Shake Milton hitting a go-ahead three-pointer with 7.2 seconds left on the clock.
The Denver Nuggets needed overtime to see off the Oklahoma City Thunder 121-113, the Washington Wizards were downed by the Indiana Pacers 111-100 and the New Orleans Pelicans beat the Memphis Grizzles 109-99.