Lewis has missed the first three games of the campaign after suffering a calf injury during his side's pre-season clash against the New York Jets over six weeks ago.
Lewis told the Florida Times-Union: "It's day to day, but I'll be out there Sunday.
"It should be awesome to get back out there and do what I do. I almost don't want to be talking right now. I just want to go practice.
"It's been tough watching other people do my job. Hopefully, I can add a spark to the offense."
Jacksonville are 0-3 in their season going into week four.