Brad Barritt is available for selection after missing the Autumn Internationals with an ankle injury, but Lancaster believes that a return is premature.
"We'll see how Brad goes," Lancaster told Sky Sports News. "It was his first training session back with us so he's been out a while.
"We have obviously got Kyle, Luther, Billy Twelvetrees, etc, and obviously on the wings as well with Marland and Christian Wade and Ben Foden being injured, so probably in the outside backs we will have to blood some experience.
"But I think now is the time to do it and find out where we are, 20 games out from the World Cup, but also at this point in this Six Nations."
The Six Nations gets underway next month.