Boro welcome the Trotters to the Riverside Stadium in the Championship with the visitors in good form.
"Bolton are a good team and they have gone eight games without losing so it won't be easy," Karanka told reporters.
"But the players have worked very hard, their attitude in training has been excellent and they've done everything I've asked of them.
"This is a game I've been looking forward to since I joined the club two weeks ago.I'm looking forward to my first home game and hopefully we can get a result against Bolton that will make the supporters happy."
The Spaniard's first match in charge was a 2-1 defeat to Leeds United last Saturday.