In Serie A, Lazio are pushing for fourth but have suffered a dip in form since breezing past Stuttgart in the last 16 of the Europa League.
They have just one win from five league games and were pegged back from 1-0 up to draw 1-1 in Monday night's Rome derby.
The Turkish side are just four points behind Galatasaray in the Turkish Super League and have won four in a row since knocking out Viktoria Plzen in the last round of Europe.
Possible starting lineups
Lazio: Marchetti; Biava, Radu, Cana, Gonzales; Candreva, Onazi, Lulic, Hernanes; Ledesma, Klose
Fenerbahce: Demirel; Kormaz, Irtegun, Ziegler; Meireles, Baroni, Topuz, Erkin; Sow, Kuyt, Webo
Sports Mole says: 3-1