Manager Ian Holloway has seen his team's automatic promotion bid come to a grinding halt, and the side must pick up three points if they are to maintain any hopes of finishing in the top two.
Barnsley have been in great form in recent weeks, picking up nine points from a possible 12 in a run that has seen them move to 20th place in the league table.
Manager David Flitcroft has seen his side pick up the majority of their points at Oakwell, but he will be confident of springing a surprise against the promotion hopefuls.
Crystal Palace: WWDLLL
Possible starting lineups
Crystal Palace: Speroni; Delaney, Ramage, Richards, Parr; Bolasie, Moritz, Jedinak; Dobbie, Zaha, Murray
Barnsley: Steele; Hassell, Wiseman, Cranie, Kennedy; Dawson, Perkins, Mellis; Dagnall, Etuhu, O'Grady
Sports Mole says: 2-2