Die Borussen head into the game on the back of three straight defeats in the league, winning just two of their eight games this season.
The dire run of results has seen last season's runners-up slip to 14th place in the table, although their form in Europe is a different matter completely.
Now the hosts must look to repeat that performance against a Hannover side who are themselves somewhat out of sorts at the moment.
Having gone three games unbeaten at the start of the season, the Reds have failed to pick up a single point in their last three outings, which includes a 3-0 home reverse at the hands of Borussia Monchengladbach last time out.
Recent league form
Borussia Dortmund: WLDLLL
Possible starting lineups
Borussia Dortmund: Weidenfeller; Piszczek, Hummels, Subotic, Sokratis; Kehl, Bender, Kagawa, Reus, Mkhitaryan; Aubameyang
Hannover: Zieler, Sakai, Marcelo, Schulz, Pander, Kiyotake, Gulselam, Schmiedebach. Bittencourt, Briand, Joselu
Sports Mole says: 2-1