The Catalan giants hold a nine-point advantage with five matches remaining, and victory at the Mendizorrotza Stadium could potentially put the club in a position where they could secure the top-flight crown on Saturday evening.
Barcelona head into this fixture having registered a hard-fought 2-1 triumph over Real Sociedad at the weekend.
Below, Sports Mole predicts what starting lineup could be named by Ernesto Valverde as the Barcelona boss attempts to keep players fresh ahead of next week's Champions League game with Liverpool.
Valverde is likely to make a number of changes for the trip to Alaves, and Lionel Messi could drop down to the bench having already completed 90 minutes on five occasions since the last international break.
Thomas Vermaelen is a huge doubt with a thigh problem, while Rafinha remains sidelined with a knee injury.