Murphy returns from a knee injury while Youngs has been released from England duty for the match.
Northampton, meanwhile, will be looking to reclaim their spot at the top of the Aviva Premiership, and welcome back Calum Clark, who was banned for 32 weeks following an incident in a match against today's opponents back in March that saw him break an opponent's elbow.
Northampton: May, Pisi, Pisi, Waldouck, Elliott, Lamb, Roberts; Tonga'Uiha, Haywood, Mujati, Manoa, Sorenson, Clark, Dawson, Van Velze
Replacements: McMillan, Waller, Doran Jones, Nutley, Oakley, Day, Burrell, Artemyev
Leicester: Murphy, Hamilton, Smith, Allen, Morris, Ford, Youngs; Ayerza, Chuter, Castrogiovanni, Deacon, Kitchener, Mafi, Salvi, Thorpe
Replacements: Stevens, Stankovich, Balmain, Slater, Noone, Harrison, Bowden, Goneva