Starting in second, Verstappen was handed a five-second penalty for his part in a first-corner incident with Charles Leclerc, while he found himself as far down the field as fifth at one point.
However, the already-crowned world champion powered back through the pack to claim a record-extending 18th victory of the campaign.
Ferrari driver Leclerc will be disappointed to have only earned second, particularly having stuck with Verstappen during the early stages when his Red Bull rival refused to give him first place back after the aforementioned incident - instead preferring to take his penalty at the first pit stop.
Nevertheless, the fact that Verstappen was back in front with 16 laps remaining and Leclerc was left requiring a last-lap overtake of Sergio Perez suggests that the end result may have been a foregone conclusion.
Chaos on the opening lap in Las Vegas as Max Verstappen takes the lead! 😲 pic.twitter.com/UckIZJzdwM— Sky Sports F1 (@SkySportsF1) November 19, 2023
Ocon went from 16th to fourth while Aston Martin's Lance Stroll brilliantly earned fifth from 19th on the grid, with Carlos Sainz Jr, Lewis Hamilton, George Russell, Fernando Alonso and Oscar Piastri claiming the minor points places.
Perez and Hamilton have now guaranteed second and third place in the Drivers Standings, but the battle is on for fourth with just 12 points separating Sainz Jr, Alonso, Lando Norris and Leclerc.
With regards to the Constructors Rankings, Mercedes are now only four points in front of Ferrari for second, with that fight going down to next week's season-concluding Abu Dhabi Grand Prix.