Zenit have lost both of their opening matches against Malaga and AC Milan, while Anderlecht have picked up a point from their first two games against the same opposition.
The home side will have to improve on their recent defensive record if they are to secure the three points. They have conceded six goals in their first two matches – the joint highest in the competition.
However, Anderlecht have gone eight group stage matches without a victory, the last coming in 2005 when they secured a 1-0 win over Real Betis.
Zenit have a virtually fully-fit squad to choose from, with the exception of Danny who remains a long-term absentee. Meanwhile, the Belgian side are still missing Matias Suarez and Cyriac to long-term injuries.
Zenit: Malafeev; Anyukov, Hubocan, Lombaerts, Criscito; Faizulin, Witsel, Shirokov; Bystrov, Kerzhakov, Hulk
Anderlecht: Proto; Gillet, Kouyate, Nuytinck, Deschacht; Yakovenko, Kanu, Biglia, Jovanovic; Mobokani, De Stutter
Sports Mole says: 3-1