In defence, Jean Beausejour replaces Leon Barnett while further forward Josh McEachran, Nick Powell, Callum McManaman and Nicky Maynard come in for James McClean, Ryan Tunnicliffe, Marc-Antoine Fortune and Martyn Waghorn.
Visitors Yeovil, meanwhile, have two changes in their starting lineup from the 3-0 defeat at Queens Park Rangers on Saturday.
Wigan: Al-Habsi; Boyce, Ramis, Perch, Beausejour; McArthur, McEachran; Gomez, Powell, McManaman; Maynard
Subs: Carson, Crainey, Rogne, McClean, Tunnicliffe, Fortune, Waghorn
Yeovil: Stech; Lanzoni, Duffy, Webster, McAllister; Grant, Edwards, Ayling, Ralls; Lawrence; Miller
Subs: Dunn, Moore, Hayter, Hoskins, Nana, Dawson, Morgan