The Latics beat Everton 3-0 last weekend to book a place in the semi-finals of the competition for the first time in their history.
Newcastle also come into the match off the back of cup success, having progressed into the last eight of the Europa League thanks to Thursday's 1-0 victory over Anzhi Makhachkala.
Alan Pardew's side have won four of their last six league games to move nine points clear of the bottom three.
Hatem Ben Arfa has been ruled out for the rest of the season, while Tim Krul and Fabriccio Coloccini are not expected to be back in action before the end of April. Rob Elliot and Mapou Yanga-Mbiwa will keep their places in the starting XI.
Possible starting lineups
Wigan: Al-Habsi; Scharner, Caldwell, Figueroa; Boyce, McCarthy, McArthur, Beausejour; Maloney, Kone, Di Santo
Newcastle: Elliot; Debuchy, Yanga-Mbiwa, Taylor, Santon; Cabaye, Tiote, Gouffran, Sissoko, Gutierrez; Cisse
Sports Mole says: 1-2