Despite sitting just one point above the relegation zone, the visitors will move into ninth position if they can record a surprise win at Estadio D. Afonso Henriques.
Having played just one match since the turn of the year, Vitoria de Guimaraes have been desperate to return to action as they bid to make their mark in the top half of the standings.
With all the teams below sixth spot taking points off each other, Guimaraes still sit ahead of the chasing pack even while possessing two matches in hand.
Only time will tell if Joao Henriques's side will benefit from the break, but it has left them having to play eight league matches over the next month.
On the back of a 2-2 draw at Moreirense, there is a feeling that Os Vimaranenses need to get back to winning ways on Thursday now that they sit five points adrift of fifth-placed Pacos de Ferreira.
Former Tottenham Hotspur youngster Marcus Edwards ended an eight-match wait for a goal by finding the back of the net on January 9.
While Guimaraes have been watching on from the sidelines, Nacional have suffered defeats to Porto in the Taca de Portugal and Moreirense in the league.
Nacional were two minutes away from knocking Porto out of the cup, eventually losing out 4-2 as their opponents outlasted them in extra time.
Further frustration followed versus Moreirense, who netted the only goal of the contest in the 78th minute to leave Luis Freire's side just a point above the relegation zone.
Having now lost five of their last six matches in Primeira Liga and with Benfica to come at the start of next week, Freire is aware that improvements are needed at Estadio D. Afonso Henriques.
Vitoria de Guimaraes Primeira Liga form: LWWWLD
Vitoria de Guimaraes form (all competitions): WLDWLD
Nacional Primeira Liga form: LLLWLL
Nacional form (all competitions): LWWLLL
Having had 12 days to prepare for this contest, Henriques is unlikely to make any significant alterations to his Guimaraes XI.
Rui Correia may feature on the substitutes' bench after serving his suspension for the red card picked up against Porto.
Vitoria de Guimaraes possible starting lineup:
Varela; Sacko, Fernandes, Mumin, Mensah; Andre, Pepelu, Almeida; Quaresma, Holm, Edwards
Nacional possible starting lineup:
Piscitelli; Freitas, Pedrao, Kal, Vigario; Borges, Micael, Azouni; Riascos, Rochez, Camacho
We say: Vitoria de Guimaraes 2-1 Nacional
Games such as this could make or break whether Guimaraes sustain a bid for a Europa League place. While we expect a scrappy encounter on Thursday night, the home side's desire to remain in contention should help them to maximum points.