With one win and one draw from their first two group matches, the two nations are locked on four points, although the Germans sit top of Group G thanks to their superior goal difference.
In terms of team selection, having come off the bench last time out, reported Manchester United transfer target Bastian Schweinsteiger could be included in the German starting lineup, with Philipp Lahm potentially reverting to a more usual full-back position.
These two sides have met on nine previous occasions, with Germany leading 6-3. Their last fixture was back in June last year, when the Americans came out on top 4-3, thanks in part to a double from Clint Dempsey.
Possible starting lineups
USA: Howard; Johnson, Cameron, Besler, Beasley; Beckerman, Jones; Bedoya, Bradley, Zusi; Dempsey
Germany: Neuer; Howedes, Hummels, Mertesacker, Lahm; Schweinsteiger, Khedira; Ozil, Kroos, Gotze; Muller
Sports Mole says: 1-2