The 44-year-old utilised a three-man defence in his side's three World Cup qualifiers in March, impressively gaining a 1-1 draw against Euro 2020 favourites France in the process.
As such, we are inclined to believe that he may approach Sunday's contest in a more cautious manner, before potentially reverting to a back four against North Macedonia and Austria.
That would mean wingers such as Oleksandr Zubkov and West Ham United's Andriy Yarmolenko potentially missing out from the start, with Atalanta BC's Ruslan Malinovskyi supporting Gent striker Roman Yaremchuk in attack.
No player made more assists than Malinovskyi in Serie A last season, so much of the creative burden is likely to fall on the 28-year-old's shoulders.
Ukraine possible starting lineup: Bushchan; Karavayev, Zabarnyi, Kryvtsov, Matviyenko, Mykolenko; Shaparenko, Sydorchuk, Zinchenko; Malinovskyi, Yaremchuk