Meanwhile, Coventry make the trip to the Liberty Stadium on the back of a 2-0 success against Brentford, by far their biggest win of the season.
On the back of seeing Brentford lose out at Coventry, Swansea boss Steve Cooper knew that his side had an opportunity to make a significant move in the Championship promotion race.
However, the Welsh side produced one of their worst performances of the season, conceding four goals in just 55 minutes to deservedly lose out at Huddersfield.
Cooper acknowledged after the fixture at the John Smith's Stadium that his players had been too passive, a reason for concern when having the chance to move ahead of Brentford with two matches in hand.
With Coventry having claimed their most eye-catching result of the campaign, Cooper will hope that Swansea's next opponents are unable to replicate their performance from the weekend.
Nevertheless, Swansea must focus on their own display, with the defeat in Yorkshire coming three days after they were fortunate to overcome struggling Nottingham Forest.
Despite remaining just five points above the relegation zone, Coventry boss Mark Robins can only be left feeling optimistic after his side's last two games.
A strong second-half showing against Norwich City earlier in the week was carried over into Saturday's game with Brentford, who were missing top goalscorer Ivan Toney.
Regardless of the absence of the Bees' star man, the Sky Blues deserve huge credit for seeing off the promotion contenders with the added bonus of a clean sheet, their second in four games after also shutting out Watford.
With just two goals being conceded in matches against the division's top three since the start of the month, Robins will see no reason why that record cannot be maintained on Wednesday.
Swansea City Championship form: WDWWWL
Swansea City form (all competitions): DWWLWL
Coventry City Championship form: DLDLLW
Barring any late fitness issues, Coventry boss Robins will likely name the same side which started the game against Brentford.
Swansea City possible starting lineup:
Woodman; Cabango, Bennett, Guehi; Roberts, Fulton, Hourihane, Bidwell; Dhanda; Ayew, Lowe
Coventry City possible starting lineup:
Wilson; Hyam, McFadzean, Ostigard; Da Costa, Kelly, Hamer, McCallum; O'Hare; Walker, Biamou
We say: Swansea City 2-1 Coventry City
Feeling that their hosts are fragile after the weekend's results, we expect Coventry to go all out for another surprise win. Nevertheless, Cooper's side will look to dominate the ball in a bid to get back on track, and they could gradually wear down opponents who still have several defeats in their short-term memory.