The Potters, who are currently in 10th place in the table, are on course to end the campaign in the top half of the Premier League for the first time.
Hughes's side would also be the highest-placed Midlands club if they hold their spot above West Bromwich Albion and Aston Villa.
"We have had a very good season, but we still have two games to go and we have a very real chance of writing history," the Welshman told the club's official website.
"We would love to end the season as the best Midlands club, and of course finishing in the top half for the first time would be a wonderful achievement."
Stoke are back in Premier League action on Saturday when they welcome Hughes's former club Fulham to the Britannia Stadium.