William Gallas and Brad Friedel should return after being rested for the trip to Slovenia, while Jake Livermore or Tom Huddlestone will deputise for Mousa Dembele in midfield, should the Belgian fail to recover from his hip injury.
Lambert may partner Jay Rodriguez in attack if Adkins opts to revert back to the 4-4-2 system which earned Southampton their only win since returning to the top flight.
Defenders Frazier Richardson and Danny Butterfield are nearing returns from injury and could be in contention, but midfielder duo Jack Cork and record signing Gaston Ramirez are definitely unavailable.
Southampton: Boruc; Clyne, Yoshia, Hooiveld, Richardson; Lallana, Davis, Schneiderlin, Puncheon; Lambert, Rodriguez
Spurs: Friedel; Walker, Gallas, Caulker, Vertonghen; Sandro, Livermore; Lennon, Dempsey, Bale; Defoe
Sports Mole says: 1-2