Andre Villas-Boas's side go into the clash having defeated Anzhi Makhachkala and Tromso, while their hosts have collected two points from the same set of fixtures.
Meanwhile, the home outfit have a large contingent of Brazil-born players, including midfielder Ricardinho, who scored last time out against Tromso. They will be without former Real Betis defender Melli, though, because of a red card that he picked up in the same game.
Spurs have faced Moldovan opposition on one previous occasion, which saw them defeat FC Zimbru Chisinau 3-0 on aggregate back in 1999.
Possible starting lineups
Sheriff: Tomic; Thuram, Samardzic, Paye, Metoua; Luvannor, Balima, Cadu, Moyal, Ricardinho; Isa
Tottenham: Lloris; Naughton, Chiriches, Kaboul, Walker; Lennon, Eriksen, Dembele, Lamela, Chadli; Defoe
Sports Mole says: 0-2