Roman Burki retains his place in the Dortmund goal despite his error leading to Stuttgart's opener in the Schwarzgelben's 2-1 defeat at the weekend.
Pierre-Emerick Aubameyang, who has 15 goals this season but has not scored since the middle of October, is recalled and will lead the line for the hosts.
Borussia Dortmund: Burki; Schmelzer, Bartra, Toljan, Weigl; Gotze, Kagawa, Guerreiro; Yarmolenko, Aubameyang, Zagadou
Subs: Weidenfeller, Philipp, Dahoud, Sahin, Schürrle, Toprak, Castro
Tottenham Hotspur: Lloris; Aurier, Sanchez, Vertonghen, Rose, Dier, Winks, Eriksen, Alli, Son, Kane
Subs: Vorm, Davies, Foyth, Trippier, Dembele, Sissoko, Llorente
Follow all the action from the Signal Iduna Park with Sports Mole's live match commentary.