Just three players keep their places from the 1-1 draw at Watford on Saturday, while the likes of Harry Kane, Hugo Lloris, Eric Dier, Christian Eriksen and Kieran Trippier are rested entirely as Spurs are already assured top spot in Group H.
Llorente starts up front against the Cypriot side, with support from Son Heung-min, who claimed the equaliser against the Hornets four days ago.
Dele Alli is joined in midfield by the returning Harry Winks, Moussa Sissoko and Georges-Kevin N'Koudou and in the backline, Serge Aurier, Juan Foyth and Danny Rose come in alongside Davinson Sanchez. Michel Vorm takes up the gloves tonight in lieu of Lloris.
As for the visitors, manager Giorgos Donis makes six changes following his side's 2-1 win over Ermis in the Cypriot First Division on Saturday.
Tottenham Hotspur: Vorm; Aurier, Sanchez, Foyth, Rose; Winks, Sissoko, Alli, Nkoudou; Son; Llorente
Subs: Gazzaniga, Davies, Vertonghen, Walker-Peters, Amos, Dembele, Sterling
APOEL: Perez; Carlao, Lago, Rueda, Vouros; Ebecilio, Vinicius, Zahid, Morais, Aloneftis; Pote
Subs: Gudino, De Camargo, Alexandrou, Sallai, Antoniou, Farias, Merkis
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