The side from the capital currently sit nine points clear at the top of the Primeira Liga table having drawn with Porto last time out, while Santa Clara returned to winning ways in their last game with an impressive 3-0 win over Pacos de Ferreira.
Ruben Amorim's men secured an important point as they played out a goalless draw with Porto, one of the sides in pursuit of the top spot, last time out.
Os Leoes look well on track to lift the 19th Primeira Liga title in their history, and their first top-flight trophy since 2002.
Amorim's side are yet to lose a game in league action this season, having picked up 55 points from a possible 63 at this stage of the campaign.
That is largely down to their strong defensive record, with no side in the division conceding as few as the 10 goals they have shipped in 21 league matches.
However, Sporting's attack has also more than pulled its weight, racking up a tally of 42 goals which is only topped by Porto.
They look to continue their march towards the league title on Friday, when they welcome a Santa Clara side with renewed confidence following an eye-catching victory last time out.
Daniel Ramos's men looked to break a run of two consecutive losses when they hosted fifth-placed Pacos de Ferreira on Saturday.
That saw Ramos's side leapfrog Moreirense and move back up to seventh in the Primeira Liga table.
They have continued their steady improvement following promotion to the top flight, after they previously finished 10th in their first season back in the Primeira Liga and ninth last campaign.
Ramos's men do boast a strong away record this season, with only four sides topping the 17 points they have recorded on the road, having won five of their 11 games on their travels this campaign.
However, that record could be under threat on Friday, as they travel to take on a formidable Sporting Lisbon side who have won 10 of their 12 league games at their home ground this season.
Sporting Lisbon Primeira Liga form: WWWWWD
Santa Clara Primeira Liga form: WDWLLW
Sporting Lisbon will be without striker Paulinho, who recently picked up a hamstring injury after joining from Braga on deadline day.
In his absence, 18-year-old Tiago Tomas will feature in a more central role again, having impressed from the wing in his first season with the first team.
He will be supported by Pedro Goncalves, who remains at the top of the league's scoring charts with 14 goals this season, despite failing to find the net in his last four league appearances.
Their only other absentee should be forward Luiz Phellype, who remains out with a long-term ligament injury.
Their attack will be full of confidence though, as Allano, Crysan and Carlos all got on the scoresheet when they formed the front three against Pacos de Ferreira.
Santa Clara used a system of three centre-backs when they took on Sporting Lisbon earlier in the season, but they are expected to stick with the four at the back system which kept a clean sheet last time out.
Sporting Lisbon possible starting lineup:
Adan; Inacio, Coates, Feddal; Porro, Mario, Palhinha, Mendes; Goncalves, Tomas, Santos
Santa Clara possible starting lineup:
Marco; Sagna, Cardoso, Villanueva, Mansur; Carvalho, Lincoln, Morita; Crysan, Carlos, Allano
We say: Sporting Lisbon 2-0 Santa Clara
We expect Sporting to get back to winning ways here after securing an important point last time out.
While Santa Clara will be positive following a good recent result, we do not see them taking points off this Sporting side, as Amorim's men look to seal their 18th league win of the campaign.