The Real Madrid defender missed his nation's 4-0 victory over Belarus on Friday night with a leg injury.
However, Del Bosque is hopeful that he will have the 26-year-old at his disposal against the French.
"He told me he was better and we are confident he'll be available for tomorrow," the coach told a press conference. "But if he cannot play we will not force the issue, we won't take risks. In that case someone else will play."
Ramos has made 96 appearances for his country.