The Saints pushed champions Manchester City close on Sunday's opener, narrowly losing out 3-2 at the Etihad Stadium.
Nigel Adkins is expected to name an unchanged lineup, although Jack Cork could be named on the bench as he continues his recovery from a foot injury. Goalscorer Rickie Lambert should also take to the field for the home side.
Southampton: Davis; Clyne, Fonte, Hooiveld, Fox; Lambert, Schneiderlin, Lallana; Puncheon, Do Prado, Rodriguez
Wigan: Al Habsi; Alcaraz, Caldwell, Boyce, Ramis; Gomez, McCarthy, McArthur, Figueroa; Moses, Di Santo
Sports Mole says: 2-2