Despite their recent run of form, the Saints have not yet scored a goal from open play, while Palace have gone three hours without being able to find the back of the net.
While there have been reports that Southampton are considering selling Rickie Lambert in January, the striker is likely to start with Pablo Osvaldo up front, while Gaston Ramirez could feature following his strike in midweek.
Crystal Palace: WDLDL
Possible starting lineups
Southampton: Boruc; Clyne, Fonte, Lovren, Shaw; Wanyama, Schneiderlin, Lallana; Rodriguez, Lambert, Osvaldo
Crystal Palace: Speroni; Mariappa, Gabbidon, Delaney, Moxey; Jedinak, Guedioura, Bannan, Puncheon; Jerome, Chamakh
Sports Mole says: 2-1