The Nerazzurri can end their recent spell of league draws with a win on away turf, while the home side are in desperate need of three points as they reside at the bottom of the table.
Siena have only clinched one win, which came against Sampdoria, in their last five games, while Inter have secured two draws in succession in the domestic league.
Inter Milan: DLDWW
Possible starting lineups
Siena: Pegolo; Neto, Felipe, Contini, Rubin, Mariano; Vergassola, Francesco, Rosina; Bogdani, Reginaldo
Inter Milan: Handanovic; Zanetti, Ranocchia, Chivu, Juan, Nagatomo; Guarin, Mudingayi, Gargano; Palacio, Cassano
Sports Mole says: 0-1