The visitors have dropped Stevie May, Chris Maguire and Jacques Maghoma from Tuesday's heavy 3-0 defeat to Wolverhampton Wanderers, and they are replaced by Lloyd Isgrove, Kamil Zayatte and Kieran Lee.
Rotherham United: Martinez, Hunt, Broadfoot, Morgan, Lafferty; Wilson, Frecklington, Smallwood, Pringle; Derbyshire, Sammon.
Subs: Collin, Brindley, Bowery, Green, Milsom, Newton, Yates.
Sheffield Wednesday: Westwood, Hutchinson, Nuhiu, Lees, Lee, Isgrove, Helan, Zayatte, Dielna, Vermijl, McGugan.
Subs: Kirkland, Lavery, May, Maguire, Buxton, Melo, Mattock.