Tachira vs. Internacional (Tuesday, 11.15pm)
The Venezuelans are hoping for a bit of payback against Colorado, who beat them 4-0 in Brazil in their second match of the group stage.
We say: Deportivo Tachira 2-4 Internacional
Losing their first match of this competition appears to have lit a fire under Internacional, who have looked almost unstoppable since then, winning four of their last five games in all competitions, scoring 19 times while conceding only three.
Deportivo have not lost this season at home, but their opponents have too many weapons who can beat you, and the Venezuelans could have their hands full trying to keep up.
The Strongest vs. Barcelona (Tuesday, 11.15pm)
While the visitors have a 100% record and three successive clean sheets, The Strongest have lost every game in Group C without scoring a goal.
We say: The Strongest 0-2 Barcelona SC
Given the respective records of the two sides, we can only predict a routine victory for the visitors. Complacency could be an issue, but Barcelona should have plenty in the tank to ease to another three points.
Santos vs. Boca Juniors (Tuesday, 11.15pm)
However, while the visitors can move six points ahead of their next opponents, Santos will move back into the mix with victory at the Urbano Caldeira Stadium.
We say: Santos 1-1 Boca Juniors
Having prevailed in the reverse fixture, Boca do not necessarily have to push for maximum points from this game. With that in mind, we are backing a competitive draw between two of South America's top sides, a result which will only favour the visitors.
Cristal vs. Racing (Wednesday, 1.30am)
While the home side have failed to win any of their opening three games in Group E, the Peruvian side know that maximum points will put them back into the mix.
We say: Sporting Cristal 1-2 Racing Club
While a lack of goals have been a problem for Cristal, they have an opportunity to put things right on Tuesday. However, the visitors are proving difficult to beat on this stage, and we expect a hard-fought win for the Argentine side.
Union La Calera vs. Flamengo (Wednesday, 1.30am)
The Chilean side have one point from their opening three matches, while the 2019 winners of this event are already guaranteed a spot in the next round of the competition.
We say: Union La Calera 1-3 Flamengo
Union are missing two critical pieces of their midfield, which should give the Brazilians plenty of time and space to counter, leaving the Chilean side vulnerable to the quick and dynamic Flamengo attack.
Independiente vs. Palmeiras (Wednesday, 1.30am)
The Ecuadorians got right back in the race for a spot in the knockout stage of this tournament by shutting out Universitario 4-0, while the defending champions remain perfect, winning all three of their games thus far.
We say: Independiente del Valle 1-3 Palmeiras
The Brazilians know what it takes to go far in this competition, and they have the tools to win it all once again.
Independiente del Valle should keep the score respectable, given they are playing at home, where they thrive, but they will have a hard time matching the speed and aggression that Palmeiras possess.