Crotone vs. Fiorentina (Saturday, 7.45pm)
With the visitors' coach also set to say farewell, after preventing them joining their hosts in Serie B next season, La Viola will hope to send Beppe Iachini off with a win.
We say: Crotone 2-2 Fiorentina
Fiorentina may have drawn a blank in consecutive weeks, but they possess at least enough firepower to breach a flimsy, absence-hit Crotone rearguard more than once on Saturday.
The hosts are going down swinging, however, and can add one final point to their meagre tally before heading back to Serie B.
Cagliari vs. Genoa (Saturday, 7.45pm)
While the visitors' much-improved second half of the season ultimately kept them afloat, their final-day hosts only secured top-flight survival last weekend.
We say: Cagliari 2-1 Genoa
Cagliari can sneak ahead of their visitors in the final standings by extending their unbeaten run to an eighth game, as with the pressure off, they can demonstrate the best of a talented squad.
As Genoa's injury woes have destabilised their defence, even a toiling Isolani attack can take advantage and reach the magical 40 points mark.
Sampdoria vs. Parma (Saturday, 7.45pm)
The Serie B-bound Crociati must win to stand a chance of avoiding last place, while their hosts will want victory as a potential leaving present for coach Claudio Ranieri, who is expected to depart Marassi at the end of the season.
We say: Sampdoria 2-0 Parma
Parma could go out with a whimper this weekend, as recent appearances suggest all life and confidence has been sucked out of their ailing attack - with the back line not faring much better.
If this is goodbye to Claudio Ranieri for Sampdoria, their various offensive options mean they can send their charismatic coach off with a positive performance and all three points at Marassi.