Grenier said that it will be a tough match as Etienne are just a place below them in the league, but is confident that his side have hit form at the right time.
"We're ready," Grenier told Ligue1.com. "We're aware that it's an important end-of-season match, but anyway the derby is always a match that stands out from the rest of the fixture list.
"Saint-Etienne are happy to have lifted the Coupe de la Ligue trophy, but we're out to win the derby and return to the Champions League.
"I feel great at the moment but it's always a bit delicate to talk about yourself because really it's all about the team. We've been through a few tough weeks but we've managed to get back on top of it."
A win would lift Lyon back above Marseille should the second-placed side fail to beat Lorient the day before.