The visitors took their tally to 12 points from their first six league matches of the season with a 1-0 home victory over Toronto, maintaining their second spot, while their hosts most recently suffered a 3-1 away defeat to New England Revolution.
New York Red Bulls suffered their fourth defeat of the MLS season on Sunday, as they travelled to take on league leaders New England Revolution.
The visitors took the lead through an early Andres Reyes goal, but the game was then turned on its head on the stroke of half time as a Gustavo Bou equaliser was quickly followed by a red card for the opening scorer Reyes.
It did not take long for the hosts to make the most of their man advantage, as they took the lead immediately before the break through Tajon Buchanan before Adam Buksa put the game out of sight with a third goal in the dying minutes.
That followed a 1-0 defeat away to Philadelphia Union, as they were unable to come back after Cory Burke's opener in the ninth minute.
With a disappointing tally of six points from their first six games of the domestic season, Gerhard Struber's side sit in 10th spot in the Eastern Conference, although with just a three-point gap between themselves and fifth-placed Atlanta United, the landscape could quickly change if the New York outfit improve their form.
That will be a tough task on Saturday, as they take on an Orlando City side who are yet to taste defeat in MLS action this season.
The visitors picked up a second consecutive victory last time out, as a Tesho Akindele goal in the 12th minute saw them to a 1-0 home win over Toronto FC.
Before that, the Lions secured another 1-0 victory, as Orlando again struck early with Mauricio Pereyra netting the winning goal after just seven minutes in their away clash against DC United.
That means Oscar Pareja's side have now won three and drawn three of their first six MLS games, putting them in a strong position in the Eastern Conference.
Currently, the Lions only trail New England Revolution by two points, while the group leaders have played a game more than Orlando, meaning Pareja's men could briefly move to the top of the table if they win on Saturday before the New England outfit play later that day.
Their strong league position is largely down to a solid defensive record, with no side in the MLS conceding as few as the two goals that Pareja's men have shipped in six matches, with four clean sheets helping them to build a strong start to the season.
They will look to extend that unbeaten run to seven games on Saturday, and put more pressure on New England Revolution at the top of the table with a victory.
New York Red Bulls defender Andres Reyes will miss out on Saturday's clash through suspension following his red card in the defeat to New England Revolution.
Defender Aaron Long is also out of action, having picked up an Achilles injury at the weekend to rule him out for an extended period of time.
Orlando City will remain without talisman Nani, who will serve the second match of his two-game suspension on Saturday, having netted three goals in his first five games of the season.
They will also be without forward Alexandre Pato through injury, although Tesho Akindele has led the line well with two goals and an assist in six MLS matches this season.
New York Red Bulls possible starting lineup:
Carlos; Edwards, Nealis, Duncan, Gutman; Casseres, Davis, Amaya, Clark; Royer, Fabio
Orlando City possible starting lineup:
Gallese; Smith, Jansson, Carlos, Schlegel; Urso, Mendez; Mueller, Pereyra, Michel; Akindele
We say: New York Red Bulls 0-2 Orlando City
The form of the two sides at the beginning of the season only suggests another victory for Orlando City on Saturday, and we see them comfortably getting past a New York Red Bulls side who are yet to hit their stride.
The hosts may struggle to break down one of the league's strongest defences, while the Lions should still have enough attacking threat to cause problems, even without Nani.