In the wake of last week's 5-1 El Clasico thrashing at the hands of Barcelona, it is now left to Solari - temporarily, at least - to pick up the pieces.
Ahead of Saturday afternoon's clash in the Spanish capital, Sports Mole looks at how Madrid could line up.
Solari has a defensive crisis of sorts for this first, and possibly only, game in charge of the senior side as regulars Carvajal, Varane and Marcelo are all ruled out.
With the versatile Nacho Fernandez likely being required at left-back, on the opposite flank to capable stand-in Alvaro Odriozola, Sergio Reguilon may come in for just a second start of the season - the other being 90 minutes in the loss to CSKA Moscow - although Nacho is equally adept at filling in in the middle.
Another alternative for Solari is to use Casemiro in the centre of defence, as was effectively the case in the second half of last week's El Clasico, which would then mean bringing in Dani Ceballos in the centre of the pitch.