Los Blancos made it eight straight league wins by beating Alaves on Friday evening and are now just two victories away from clinching the title.
As it stands, the gap to second-placed Barcelona is four points, although the reigning champions will have the chance to move to within one point when they face Real Valladolid on Saturday night.
Here, Sports Mole looks at how Madrid could line up when they take to the field against Granada, who are currently ninth in Spain's top flight.
Madrid were without the services of both Dani Carvajal and Sergio Ramos against Alaves through suspension, but the pair are expected to return to the XI for this match, with Lucas Vazquez and Eder Militao dropping out.
Zidane has plenty of options for change all over the park, but the Frenchman is expected to resist the temptation to shuffle his pack, with the five-substitute rule allowing him to keep his players fresh.